Whereas OSKM can revert differentiated cells into induced pluripotent stem cells, in vivo partial reprogramming likely works by reinvigorating adult stem cell pools – allowing aged tissues to regenerate. The Stem Cell Maintenance and Differentiation Formula focuses on preserving the self-renewal capacity of stem cells and guiding their healthy differentiation into new tissue. In essence, it creates a nurturing niche for stem cells, much like the embryonic niche created transiently during partial reprogramming. Natural compounds in this formula activate pro-stem cell pathways (like SIRT1, cAMP/PKA, Wnt) and protect stem cells from exhaustion, thereby initiating tissue rejuvenation at the source.
