Chronic inflammation is a well-known driver of aging – it reinforces cellular senescence and disrupts tissue regenerative capacity (inflammaging). Moreover, inflammatory signaling (e.g. NF-κB activation) is antagonistic to Yamanaka-factor reprogramming; NF-κB can block factors like Oct4 and Sox2 from inducing a youthful state by maintaining stress responses. The Anti-Inflammatory Cellular Repair Formula is therefore critical in creating a permissive environment for rejuvenatione. By suppressing pro-inflammatory pathways (COX-2, NF-κB, TNF-α, etc.) and reducing the SASP, it removes the “brakes” that inflammation puts on tissue repair and cellular reprogramming. Essentially, it mimics the low-inflammation environment of youth, which is conducive to regeneration and partial reprogramming.
