A hallmark of aging is drift in the epigenetic landscape – DNA methylation patterns and histone marks become dysregulated. Yamanaka factor reprogramming wipes aging-associated epigenetic marks, restoring a youthful transcriptional program. The Epigenetic Reset Formula similarly aims to reset the epigenome, but using phytochemicals that target chromatin-modifying enzymes. By modulating DNA methyltransferases and histone acetylases/deacetylases, this formula erases or “loosens” aberrant epigenetic marks, reactivating silenced youthful genes and silencing pro-aging genes. The result is a gene expression profile reflective of a younger cell – comparable to the changes seen in partially reprogrammed cells.
