HH-321
HH-321 is a novel phytotherapeutic supplement formulated to mimic and enhance the effects of ipamorelin through a synergistic blend of phytotherapeutic extracts. This white paper presents a comprehensive review of HH-321’s formulation, mechanistic pathways, and potential clinical benefits in the context of aging and metabolic disorders.
Seven evidence-backed phytptherapeutics – Mucuna pruriens, Withania somnifera (ashwagandha), fenugreek, Rhodiola rosea, Panax ginseng, Astragalus membranaceus, and Ginkgo biloba – are combined in specific ratios to promote GH release, support lean muscle mass, improve recovery, and enhance sleep quality. Each ingredient contributes unique bioactive compounds (L-DOPA, withanolides, saponins, rosavins, ginsenosides, astragalosides, flavone glycosides) that target neuroendocrine or metabolic pathways associated with GH regulation.
CU-464
CU-464 is a novel phytotherapeutic peptide mimetic, designed as a copper-binding peptide with potent regenerative properties for skin and hair follicles. Copper peptides like glycyl-L-histidyl-L-lysine (GHK-Cu) have emerged as powerful agents to repair tissue and stimulate new hair growth. CU-464 is a next-generation copper peptide mimetic inspired by these natural peptides, formulated to harness copper’s role in enzymatic tissue repair and regeneration. As a phytotherapeutic mimetic, CU-464 is uniquely combined with botanical extracts known for dermatological benefits. The inclusion of Centella asiatica (Gotu Kola), Equisetum arvense (horsetail), and Camellia sinensis (green tea) is designed to provide synergistic mechanisms – from stimulating collagen synthesis to providing antioxidant and anti-inflammatory support.
VF-210.42
VF-210.42 is a novel plant-derived formulation designed as a peptide mimetic of bremelanotide (PT-141), a melanocortin-4 receptor agonist used to treat hypoactive sexual desire disorder (HSDD). Unlike hormonal therapies, PT-141 enhances libido via central nervous system (CNS) pathways without altering endocrine levels. VF-210.42 combines seven bioactive botanicals – Muira puama, Damiana, Maca, Horny Goat Weed (Epimedium), Catuaba, Tribulus terrestris, and Saffron – selected for their synergistic aphrodisiac properties and mechanistic overlap with melanocortin pathway effects.
FOX-Y22
FOX‐Y22 is a phytotherapeutic formulation modeled after the peptide senolytic FOXO4-DRI. It consists of eight plant-derived compounds – fisetin, quercetin, piperlongumine, curcumin, epigallocatechin gallate (EGCG), resveratrol, berberine, and apigenin – combined in defined ratios. Each component has demonstrated senotherapeutic properties in peer-reviewed studies, including the ability to selectively induce apoptosis of senescent cells and/or suppress the pro-inflammatory senescence-associated secretory phenotype (SASP).
SIPP-432
Sleep Inducing Phytotherapeutic Peptide Mimetic
SIPP-432 research has demonstrated induction of delta (slow-wave) sleep and associated growth hormone release, reduction of stress hormone (corticotropin) levels, and broad stress-protective or adaptogenic effects. SIPP also exhibits neuroprotective properties, improving outcomes in ischemic brain injury and reducing oxidative stress in the central nervous system. The formulation comprises Magnolia officinalis, Valeriana officinalis (valerian), Passiflora incarnata (passionflower), Withania somnifera (ashwagandha), Ziziphus spinosa (jujube seed), Scutellaria lateriflora (skullcap), Apocynum venetum (Luobuma), and L-theanine
EGH-123
Elevating Growth Hormone Phytotherapeutic Peptide Mimetic
EGH-123™ embodies a novel phytotherapeutic approach to enhancing growth hormone output and modulating the endocrine system in a comprehensive yet balanced manner. Through a synergistic blend of nine plant-based extracts, EGH-123 targets multiple pathways – from stimulating pituitary GH release and peripheral IGF-1 activity to optimizing stress and metabolic hormone levels – thereby delivering five core benefits highly sought by both consumers and clinicians: accelerated muscle growth, anti-aging effects, improved sleep quality, enhanced fat metabolism, and holistic endocrine regulation.
Thymo-500
Thymo-500™ is a novel phytotherapeutic formulation designed to mimic and enhance the regenerative properties of thymosin beta-4 (TB-500), a peptide known for promoting wound healing, angiogenesis, and tissue repair. Each component is selected for scientifically verified mechanisms that parallel TB-500’s actions, including actin cytoskeletal remodeling, enhanced cellular migration, accelerated collagen synthesis, modulation of inflammation, and stem cell support in damaged tissues.
PHYTO-888
Phyotherapeutic Peptide Mimetic
Phyto-888™ is a novel full-spectrum phytotherapeutic formulation designed to mimic the broad tissue-healing and regenerative effects of the synthetic peptide BPC-157.
BPC-157 is renowned for accelerating wound and musculoskeletal healing, promoting angiogenesis, protecting the gastric mucosa, dampening inflammation, and fostering neuroregeneration.
Phyto-888™ combines evidence-based phytomedicines – Centella asiatica, Curcuma longa, Astragalus membranaceus, Salvia miltiorrhiza, Panax notoginseng, Boswellia serrata, Calendula officinalis, Glycyrrhiza glabra, Gynostemma pentaphyllum, and Rhodiola rosea – to recapitulate these therapeutic pathways.
PINE-963
PINE-963 is a multi-component phytotherapeutic formulation designed to mimic the telomerase-activating and longevity-enhancing effects of the synthetic peptide Epitalon (Epithalon). Epitalon is a pineal tetrapeptide shown to upregulate telomerase, elongate telomeres, and extend cellular lifespan beyond the Hayflick limit. To replicate these geroprotective mechanisms, PINE-963 combines Astragalus membranaceus (cycloastragenol-rich extract), Rhodiola rosea, Withania somnifera (ashwagandha), Bacopa monnieri, Curcuma longa (curcumin), Ginkgo biloba, Resveratrol, and epigallocatechin gallate (EGCG) from green tea. Each ingredient is supported by evidence for telomerase activation, telomere maintenance, or anti-aging effects, with a focus on mitigating aging-related neurodegeneration and immune decline.
TRI-P11
Concurrently, various phytotherapeutic agents mimic or synergize with TRI-P11’s mechanism of action. Glycyrrhiza glabra (licorice), Boswellia serrata (frankincense), Curcuma longa (turmeric), Aloe barbadensis (aloe vera), Chamomilla recutita (chamomile), Plantago ovata (psyllium), Calendula officinalis (calendula), and Andrographis paniculata each possess anti-inflammatory and mucosal healing activities rooted in peer-reviewed evidence. These phytotherapeutics modulate immune responses (e.g. inhibiting NF-κB, cytokines, and eicosanoids) and promote intestinal barrier repair in models of gut inflammation
Explore The
Peptideverse
Phytotherapeutic Peptide Mimetics: A Natural Paradigm for Functional Regeneration and Wellness
The rising success of synthetic therapeutic peptides in functional and regenerative medicine has sparked an emerging movement to identify phytotherapeutic mimetics—plant-based bioactive compounds that emulate the physiological benefits of these peptides through parallel or downstream pathways. Here we integrate the safety, accessibility, and complex synergy of plant medicine with the mechanistic precision of peptide pharmacology.