FOX‐Y22 is a phytotherapeutic formulation modeled after the peptide senolytic FOXO4-DRI. It consists of eight plant-derived compounds – fisetin, quercetin, piperlongumine, curcumin, epigallocatechin gallate (EGCG), resveratrol, berberine, and apigenin – combined in defined ratios. Each component has demonstrated senotherapeutic properties in peer-reviewed studies, including the ability to selectively induce apoptosis of senescent cells and/or suppress the pro-inflammatory senescence-associated secretory phenotype (SASP).
