OncoReset
OncoReset creates a cellular environment conducive to cancer reprogramming by reducing inflammation and clearing senescent cells, which can secrete SASP factors that promote malignancy. This supports OncoShield’s epigenetic effects by removing barriers to reprogramming.
Key Phytoverse Ingredients and Mechanisms:
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Curcumin (Turmeric): Inhibits NF-κB, reducing inflammatory cytokines (e.g., IL-6, TNF-α) that can interfere with reprogramming, as noted in the KAIST report’s emphasis on a low-inflammatory environment.
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Boswellia serrata (Frankincense): Provides boswellic acids that inhibit 5-LOX and NF-κB, reducing leukotrienes and supporting a pro-regenerative niche, which complements cancer cell reversion.
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Fisetin (Fruits): A potent senolytic that clears senescent cells, reducing SASP factors like IL-6, which can block MYB/FOXA2 downregulation by maintaining a pro-tumorigenic environment.
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Resveratrol (Grape Skin): Inhibits NF-κB via SIRT1 activation, lowering inflammation and supporting epigenetic stability during reprogramming. Resveratrol also has mild HDAC inhibitory effects.
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Withania somnifera (Ashwagandha): Withaferin A induces apoptosis in cancer cells while promoting stress resistance in normal cells, supporting selective clearance of malignant cells and reducing inflammation.
OncoBalance
OncoBalance supports the energy demands of cancer cell reprogramming by enhancing mitochondrial function and optimizing metabolism, while creating a metabolic environment that disfavors cancer cell survival. It complements the epigenetic and anti-inflammatory effects of OncoShield and OncoReset.
Key Phytoverse Ingredients and Mechanisms:
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Berberine (Coptis, Berberis): Activates AMPK, which can indirectly suppress MYB-driven proliferation by shifting cells into a catabolic state that disfavors cancer growth. Berberine also enhances mitochondrial biogenesis via PGC-1α.
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Resveratrol (Grape Skin): Activates SIRT1 and AMPK, supporting mitochondrial health and reducing oncogenic signaling (e.g., PI3K/Akt) that can upregulate MYB and FOXA2.
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Gynostemma pentaphyllum (Jiaogulan): Contains gypenosides that activate AMPK, boosting mitochondrial density and insulin sensitivity, creating a metabolic state that supports reprogramming.
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Spermidine (Wheat Germ, Soy): Induces autophagy, clearing damaged mitochondria and reducing oxidative stress, which can support cancer cell reversion by maintaining cellular health.
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Astragalus membranaceus (Astragalus): Provides astragaloside IV, which activates telomerase and supports cellular longevity, but must be used cautiously due to potential cancer risks associated with hyper-long telomeres (as noted in prior discussions).
OncoShield
OncoShield directly targets MYB, HDAC2, and FOXA2 downregulation through epigenetic modulation, initiating the non-destructive reprogramming of cancer cells into a normal-like state, as demonstrated by KAIST. It leverages Phytoverse ingredients known for their effects on transcription factors and histone modifications.
Ingredients and Mechanisms:
· Curcumin: Inhibits HDAC2 by reducing its activity and expression, as noted in studies showing curcumin’s ability to restore tumor suppressor gene expression in cancer cells. Curcumin also suppresses NF-κB, which can indirectly reduce MYB-driven proliferation by modulating upstream pathways.
· EGCG : Modulates transcription factor activity and epigenetics, potentially downregulating FOXA2 by inhibiting its promoter activity, as seen in studies on gastrointestinal cancers. EGCG also inhibits HDAC activity, supporting HDAC2 suppression.
· Sulforaphane: Inhibits HDACs (including HDAC2) and activates Nrf2, creating an epigenetic environment that favors gene silencing of oncogenic drivers like MYB. Sulforaphane’s DNMT-inhibitory activity further supports epigenetic reprogramming.
· Genistein: Downregulates FOXA2 by targeting upstream pathways like PI3K/AKT, which FOXA2 interacts with to maintain cancer cell identity. Genistein also has mild HDAC inhibitory effects.
· Quercetin: Reduces MYB expression by inhibiting upstream regulators like c-Myc and supports HDAC inhibition, enhancing the epigenetic reset of cancer cells.
Lymphoverse™
Phytotherapeutic Resilience Terrain Modulation
for Optimal Lymphatic Health
Lymphoverse™ represents a targeted, phytotherapeutic approach designed specifically to enhance lymphatic health and resilience, particularly beneficial in contexts of lymphatic system compromise and melanoma-associated lymphatic impact.
Utilizing scientifically validated herbal extracts, Lymphoverse™ optimizes lymphatic flow, modulates immune responses, and promotes detoxification processes essential for maintaining lymphatic integrity.
Lymphoverse™ leverages phytotherapeutic extracts synergistically to modulate epigenetic regulators, immune function, inflammation, and detoxification processes. This holistic approach enhances lymphatic resilience and creates an unfavorable terrain for melanoma progression, significantly supporting overall lymphatic health.
