OncoReset creates a cellular environment conducive to cancer reprogramming by reducing inflammation and clearing senescent cells, which can secrete SASP factors that promote malignancy. This supports OncoShield’s epigenetic effects by removing barriers to reprogramming.
Key Phytoverse Ingredients and Mechanisms:
Curcumin (Turmeric): Inhibits NF-κB, reducing inflammatory cytokines (e.g., IL-6, TNF-α) that can interfere with reprogramming, as noted in the KAIST report’s emphasis on a low-inflammatory environment.
Boswellia serrata (Frankincense): Provides boswellic acids that inhibit 5-LOX and NF-κB, reducing leukotrienes and supporting a pro-regenerative niche, which complements cancer cell reversion.
Fisetin (Fruits): A potent senolytic that clears senescent cells, reducing SASP factors like IL-6, which can block MYB/FOXA2 downregulation by maintaining a pro-tumorigenic environment.
Resveratrol (Grape Skin): Inhibits NF-κB via SIRT1 activation, lowering inflammation and supporting epigenetic stability during reprogramming. Resveratrol also has mild HDAC inhibitory effects.
Withania somnifera (Ashwagandha): Withaferin A induces apoptosis in cancer cells while promoting stress resistance in normal cells, supporting selective clearance of malignant cells and reducing inflammation.
